Process filtration removes particles, microorganisms, and dissolved contaminants from liquids, gases, and process streams using a graded series of technologies — cartridge, micro-, ultra-, nano-, and depth filtration — sized and integrated into your high-purity water, product, and utility systems. Paul Industries designs, sizes, fabricates, and installs process filtration as part of a single-source sanitary system, tying filter housings and sterilizing-grade filters into ASME BPE piping for pharmaceutical, biotech, cosmetic, and food & beverage facilities across the United States, with more than 30 years of cGMP/FDA-compliant experience.

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What it isIntegration of graded filtration into water, product & utility streams
Who it’s forcGMP pharma, biotech, cosmetic, nutraceutical & food/beverage plants
TechnologiesCartridge · micro · ultra · nano · depth/rotary · sterilizing-grade
ScopeSizing → housing selection → piping tie-in → integrity testing → validation
StandardsASME BPE · cGMP / 21 CFR 211 · sterilizing-filtration & integrity-test practice
Service areaNationwide (all 50 states)

How process filtration works

Filtration works by placing a barrier of a defined pore size in the flow path so that contaminants larger than the rating are retained while the process fluid passes through. Different mechanisms dominate at different scales: coarse depth and cartridge filters capture particles by a combination of sieving and entrapment within a thick media bed, while membrane filters — microfiltration, ultrafiltration, and nanofiltration — separate progressively smaller species down to microorganisms, macromolecules, and multivalent ions. The correct choice depends on what must be removed, the required throughput, and where the filter sits in the overall process.

In a real facility, filtration is rarely a single device — it is a train. A typical arrangement uses depth or cartridge prefilters to protect a final membrane, a sterilizing-grade filter immediately upstream of a fill or point of use, and vent filters on tanks and housings. Paul Industries treats filtration as system integration: we size each stage for its duty, select the housing and connection style, and tie the filter into the surrounding sanitary piping so the assembly is drainable, sanitizable, and integrity-testable in place rather than bolted on as an afterthought.

Filtration types by pore size and application

The four membrane and cartridge classes below are defined by the size of what they retain. Most systems combine several stages, using a coarser filter to protect a finer one.

Filtration types by pore size and typical application
TypeTypical ratingRemovesTypical application
Cartridge / depth~1–100 µmParticulates, sediment, carbon finesPrefiltration, feed-water & utility protection
Microfiltration (MF)~0.1–1 µmBacteria, larger particulates, some cellsSterilizing-grade (0.2 µm), clarification, prefilter
Ultrafiltration (UF)~0.001–0.1 µmViruses, endotoxin, proteins & macromoleculesEndotoxin reduction, product concentration, WFI support
Nanofiltration (NF)~0.001 µm rangeMultivalent ions, small organics, hardnessSoftening, partial demineralization, selective separation

Ratings are approximate and overlap between classes; the practical boundaries depend on membrane chemistry and the manufacturer’s validated rating. Rotary and depth filtration are used where high solids loads would quickly blind a membrane, serving as robust upstream clarification before the finer stages.

Our process filtration services

Paul Industries delivers filtration as part of an integrated sanitary scope, so one team is accountable for the filter and the piping it sits in:

  • Filtration sizing & selection — matching filter type, area, and rating to flow, contaminant load, and change-out interval so stages are neither undersized nor wasteful.
  • Cartridge & membrane filtration — cartridge, micro-, ultra-, nano-, and depth/rotary stages specified for their duty in the train.
  • Sterilizing-grade filters — 0.2 µm (and 0.1 µm) final filters for liquids and vent/gas service, installed so they can be tested and changed cleanly.
  • Filter housings & assemblies — sanitary single- and multi-round housings, capsules, and sterilizing vent filters selected for pressure, temperature, and drainability.
  • Sanitary piping tie-in — orbital-welded, drainable connections to your high-purity water loops, product lines, and utilities per ASME BPE.
  • Integrity testing & validation — filter integrity testing (bubble-point / diffusion / pressure-hold) and IQ/OQ/PQ support so the installed filter is documented and proven.

Industries we serve

We integrate process filtration for pharmaceutical and biotech drug manufacturing (sterilizing-grade filtration of buffers, media, and final product, plus vent and WFI-support filtration), cosmetic and personal-care blending and filling lines, nutraceutical production, and food & beverage plants where clarification and microbial control matter. Each industry differs in fluid chemistry, throughput, and documentation, and we tailor the media, housing, and integrity-test approach accordingly.

Standards & compliance

ASME BPE (Bioprocessing Equipment)
Governs the hygienic design, materials, surface finish, and weld quality of the sanitary piping and housing connections a filter ties into — so the installed filter assembly is drainable and cleanable.
cGMP / 21 CFR 211
FDA current Good Manufacturing Practice requirements that make filtration a controlled, documented step — the reason sterilizing filters are specified, integrity-tested, and recorded rather than simply installed.
Sterilizing filtration & integrity testing
Sterilizing-grade liquid filters are generally rated at 0.2 µm and validated for bacterial retention; each installed filter is verified by a non-destructive integrity test — bubble point, diffusion (forward flow), or pressure hold — following widely used ASTM and PDA technical practice for filter integrity testing.
IQ / OQ / PQ
Installation, Operational, and Performance Qualification prove the filtration system was built correctly, operates within its parameters, and consistently performs to specification before routine use.

Why Paul Industries

A filter is only as good as the piping and housing around it — a poorly drained housing or a dead leg upstream of a sterilizing filter undermines the whole stream. Because Paul Industries self-performs sizing, sanitary-piping fabrication, installation, and integrity testing, one team owns the filter and its connections, with no gap between the engineer who sizes the stage, the welder who ties it in, and the technician who integrity-tests it. Our crews have built process-equipment and high-purity systems across the United States for more than three decades, and every weld and test is documented for cGMP traceability. Where public project references are limited by client confidentiality, we provide capability statements, weld and material documentation, and integrity-test and validation deliverables on request.

Frequently asked questions

What is process filtration?
Process filtration removes particles, microorganisms or contaminants from a fluid or gas stream during manufacturing. It ranges from coarse prefiltration to sterilizing-grade membrane filtration, protecting product quality, equipment and sterility. In pharma and biotech it is essential for WFI, media, buffers, final fill and vent-gas applications.
What is the difference between microfiltration and ultrafiltration?
Microfiltration uses membranes around 0.1 to 10 microns to remove bacteria, particulates and cells. Ultrafiltration uses much finer membranes rated by molecular weight cutoff to retain proteins, viruses and macromolecules while passing water and salts. Microfiltration clarifies and sterilizes; ultrafiltration concentrates and purifies at the molecular level.
What is a sterilizing-grade filter?
A sterilizing-grade filter is a membrane, typically rated 0.22 micron, validated to remove bacteria and produce a sterile filtrate, confirmed by bacterial-challenge testing with Brevundimonas diminuta. It is used for final sterile filtration of liquids and for sterilizing process gases and vents where terminal sterilization is not possible.
What is the difference between depth and membrane filters?
Depth filters use a thick, tortuous matrix to trap particles throughout their volume, ideal as prefilters for high solids loads and clarification. Membrane filters remove particles at a defined surface pore size, giving absolute, validatable retention for sterilizing or fine filtration. Depth filters protect membranes from premature clogging.
What is a filter integrity test?
A filter integrity test non-destructively confirms a sterilizing-grade filter is intact and correctly rated before and after use, using bubble-point, diffusion or pressure-hold methods. Passing correlates to validated bacterial retention. It is a cGMP requirement for sterile filtration to prove the filter did not have a defect.
What is bubble point in filtration?
Bubble point is the pressure at which gas first pushes liquid out of a wetted filter’s largest pore, correlating to pore size and filter integrity. A measured bubble point at or above the validated value confirms the membrane is intact and correctly rated. It is a standard integrity-test method.
What is tangential flow filtration?
Tangential flow filtration, also called crossflow, passes feed parallel to the membrane so retained material sweeps across rather than building a cake on the surface. This sustains flux and suits concentration and diafiltration of proteins and cells. It contrasts with dead-end filtration, where flow goes straight through.
What is the difference between dead-end and crossflow filtration?
Dead-end filtration drives all fluid through the membrane, trapping solids on the surface until it clogs, simple and used for low-solids sterile filtration. Crossflow (tangential) sweeps feed across the membrane to limit fouling, suited to high-solids concentration and diafiltration. The choice depends on solids load and duty.
How do you size a process filter?
Filter sizing balances required flow rate, allowable pressure drop, total throughput before clogging, fluid viscosity and particulate load, and validated retention. Undersizing clogs prematurely and stalls the batch; oversizing wastes cost and holdup volume. Sizing trials on the actual fluid confirm area. Paul Industries sizes to the process.
What causes a process filter to clog prematurely?
Premature clogging comes from high particulate or colloid load, missing prefiltration, undersized area, fouling-prone product, or incompatible membrane chemistry. Adding a graded prefilter train, sizing correctly and matching membrane material extend filter life. Paul Industries designs multi-stage trains to protect final filters.
What is a vent filter used for?
A vent filter is a sterilizing-grade, often hydrophobic, membrane on a tank or vessel that lets air move in and out during filling and draining while blocking microbial and particulate ingress. It keeps sterile or clean contents protected. Hydrophobic media prevent water blockage and support integrity testing.
What materials are process filter membranes made from?
Common membranes include PES (polyethersulfone) for broad liquid filtration, PVDF, nylon, PTFE for hydrophobic gas and vent use, and cellulose or glass-fiber depth media. Material is chosen for chemical compatibility, protein binding, wettability and retention. Paul Industries specifies membrane chemistry suited to the fluid and duty.
How is process filtration validated?
Sterile filtration is validated through bacterial-challenge testing correlating integrity-test values to retention, plus extractables, adsorption and compatibility studies, filter-integrity testing each use, and documented IQ/OQ/PQ of the housing and system. Paul Industries builds this documentation to cGMP and FDA expectations.
What is the difference between filtration and purification?
Filtration physically separates particles or microbes by size through a membrane or medium. Purification is the broader goal of removing impurities, achieved by filtration plus chromatography, ion exchange, RO/DI and other steps. Filtration is one tool within a purification train, often the final sterilizing or polishing step.
Do you design and install process filtration systems nationwide?
Yes. Paul Industries designs, fabricates, installs and validates process-filtration skids and housings, prefiltration, sterile, vent and crossflow, integrated with sanitary piping and integrity testing across all 50 states as a single-source contractor from Kilmarnock, Virginia. Call 201-450-8280.
How do I specify a process filtration system?
Specify the fluid or gas, flow rate, particulate or bioburden load, required retention, batch volume, and sanitary and validation requirements. Paul Industries reviews these, selects membrane chemistry and area, and delivers an installed, validated filtration system. Call 201-450-8280.
What filtration do I need for my process?
It depends on what you must remove and where the filter sits. Particulate and sediment call for cartridge or depth filtration; bacterial removal calls for microfiltration, typically a 0.2 µm sterilizing-grade filter; virus, endotoxin, and macromolecule removal calls for ultrafiltration; and selective removal of multivalent ions or hardness calls for nanofiltration. Most systems combine stages, and we size the train during design based on your fluid, contaminant load, and throughput.
What is sterilizing-grade filtration and integrity testing?
A sterilizing-grade filter — generally rated at 0.2 µm and validated for bacterial retention — provides a sterile, particle-free stream at a point of use or fill. Because the membrane cannot be inspected directly, each installed filter is verified by a non-destructive integrity test such as bubble point, diffusion (forward flow), or pressure hold, following established ASTM and PDA practice. We install filters so they can be integrity-tested in place and document the result for cGMP records.
Do you integrate filtration into existing systems?
Yes. We routinely add or upgrade filtration in existing high-purity water loops, product lines, and utilities — evaluating flow, pressure drop, drainability, and dead legs, then tying in housings and sterilizing filters with sanitary, documented connections and minimal disruption to production.
How do you choose between a cartridge and a housing?
The cartridge (or capsule) is the filter media rated for the separation; the housing is the sanitary pressure vessel that holds it. We select the cartridge by rating, chemistry, and required area, then match the housing style — single- or multi-round, sanitary or capsule — to pressure, temperature, flow, drainability, and change-out ergonomics, so the assembly is both effective and serviceable.
Do you validate the filtration system?
Yes. We provide filter integrity testing and IQ/OQ/PQ support, so the same team that sizes and installs the filtration also documents and proves it operates and performs to specification.
Which states do you serve?
We are Virginia-based and integrate process filtration systems nationwide.

Get a process filtration quote

Tell us about your fluid, contaminant, required rating, and flow — a Paul Industries engineer will follow up to discuss sizing, standards, and timeline.

Request a Project Quote or call 201-450-8280

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